The erbb receptor gene family consists of the egfr gene erbb her1 erbb2 her2 neu erbb3 her3 and erbb4 her4 the frequent selection of erbb2 her2 neu and less often the epidermal growth factor receptor and erbb3 for overexpression in breast cancer implies that these receptors have important functions in normal mammary gland development. The epidermal growth factor family of receptor tyrosine kinases erbbs plays essential roles in regulating cell proliferation survival differentiation and migration the erbb receptors carry out both redundant and restricted functions in mammalian development and in the maintenance of tissues in the adult mammal. Epidermal growth factor receptor mechanisms of activation and signaling the deaf and dumb the biology of erbb 2 and erbb 3 erbb 4 mechanism of action and biology trafficking of the erbb receptors and its influence on signaling erbbs in mammary development the erbb receptors and their role in cancer progression. Mammalian kidney expresses all of the members of the erbb family of receptors and their respective ligands studies support a role for erbb family receptor activation in kidney development and differentiation under physiologic conditions egfr activation appears to play an important role in the . The epidermal growth factor receptor is a member of the erbb family of receptors a subfamily of four closely related receptor tyrosine kinases egfr erbb 1 her2 neu erbb 2 her 3 erbb 3 and her 4 erbb 4 in many cancer types mutations affecting egfr expression or activity could result in cancer
How it works:
1. Register a Free 1 month Trial Account.
2. Download as many books as you like ( Personal use )
3. No Commitment. Cancel anytime.
4. Join Over 100.000 Happy Readers.
5. That's it. What you waiting for? Sign Up and Get Your Books.